Overview

  • Product name

    Z-LEHD-FMK, caspase-9 inhibitor
  • Description

    Irreversible caspase-9 inhibitor
  • Biological description

    Irreversible caspase-9 inhibitor. Selective anti-apoptotic reagent, does not inhibit apoptosis in all biological systems. Neuroprotective. Cell-permeable. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    210345-04-3
  • Chemical structure

    Chemical Structure

Properties

Images

  • Differentiated muscle cells were pre-incubated with 20 µM Z-LEHD-FMK (irreversible caspas-9 inhibitor) for 30 min before exposure to anoxic conditions. C) Light microscopy pictures demonstrates morphological changes during anoxia treatment. Arrows indicate rounded up, dead cells. D) Live/dead analysis demonstrate increased number of dead cells during 6 h anoxia, but this is unaffected by the irreversible caspase-9 inhibitor.

  • Functional assays: Caspase 9 Inhibitor Drug Detection Kit (ab102497)

    Titration of the caspase 9 inhibitor Z-LEHD-FMK (ab142026) (duplicates; +/- SD).

References

This product has been referenced in:

  • Cowburn AS  et al. z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species. Blood 105:2970-2 (2005). Read more (PubMed: 15572588) »
  • Colak A  et al. Neuroprotection and functional recovery after application of the caspase-9 inhibitor z-LEHD-fmk in a rat model of traumatic spinal cord injury. J Neurosurg Spine 2:327-34 (2005). Read more (PubMed: 15796358) »
  • Wu Z  et al. Shikonin regulates HeLa cell death via caspase-3 activation and blockage of DNA synthesis. J Asian Nat Prod Res 6:155-66 (2004). Read more (PubMed: 15224412) »
  • Ozoren N  et al. The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res 60:6259-65 (2000). Read more (PubMed: 11103780) »
See 1 Publication for this product

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