Overview

  • Product name

    Z-Leu-Leu-CHO, Calpain inhibitor
  • Description

    Calpain inhibitor
  • Biological description

    Calpain inhibitor. Attenuates ischemia reperfusion injury in vivo. Cell permeable. Active in vivo and in vitro.
  • Purity

    > 98%
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    362.50
  • Molecular formula

    C20H30N2O4
  • Sequence

    LL (Modifications: N-terminal benzyloxycarbonyl; C-terminal aldehyde)
  • PubChem identifier

    456427
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM and in ethanol to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Jeong JC  et al. Silibinin induces apoptosis via calpain-dependent AIF nuclear translocation in U87MG human glioma cell death. J Exp Clin Cancer Res 30:44 (2011). Read more (PubMed: 21501525) »
  • Gailly P  et al. In situ measurements of calpain activity in isolated muscle fibres from normal and dystrophin-lacking mdx mice. J Physiol 582:1261-75 (2007). Read more (PubMed: 17510188) »
  • Ikeda Y  et al. Attenuation of neutrophil-mediated myocardial ischemia-reperfusion injury by a calpain inhibitor. Am J Physiol Heart Circ Physiol 282:H1421-6 (2002). Read more (PubMed: 11893579) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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