Overview

  • Product name

    Z-LLY-FMK, Calpain inhibitor
  • Description

    Irreversible, cell-permeable calpain inhibitor
  • Biological description

    Irreversible, cell-permeable calpain inhibitor. Reduces Gal-9-induced apoptosis in vitro. Suppresses hepatocyte apoptosis after bile duct ligation in rat. Active in vivo and in vitro.
  • Purity

    > 95%
  • CAS Number

    133410-84-1
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    557.70
  • Molecular formula

    C30H40FN3O6
  • Sequence

    LLY (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK)
  • PubChem identifier

    16760337
  • Storage instructions

    Store at -20°C (desiccating conditions).
  • Solubility overview

    Supplied in DMSO (10 mM)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)CF)NC(=O)C(CC(C)C)NC(=O)OCC2=CC=CC=C2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sangeetha V  et al. Expansion of cord blood CD34 cells in presence of zVADfmk and zLLYfmk improved their in vitro functionality and in vivo engraftment in NOD/SCID mouse. PLoS One 5:e12221 (2010). Read more (PubMed: 20808921) »
  • Sheen-Chen SM  et al. Z-LLY-FMK attenuates intestinal apoptosis after bile duct ligation in rats. Dig Dis Sci 54:2357-61 (2009). Read more (PubMed: 19093200) »
  • Sheen-Chen SM  et al. Z-LLY-FMK can attenuate hepatocyte apoptosis after bile duct ligation in rat. Dig Dis Sci 53:2975-9 (2008). Read more (PubMed: 18592378) »
  • Kashio Y  et al. Galectin-9 induces apoptosis through the calcium-calpain-caspase-1 pathway. J Immunol 170:3631-6 (2003). Read more (PubMed: 12646627) »

Customer reviews and Q&As

Answer



The FMK peptide inhibitor binds to the calpain substrate site and prevents its substrate binding, thereby inhibiting its activity.

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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