- References (11)
DescriptionIrreversible general caspase inhibitor
An irreversible general caspase inhibitor. Non cell-permeable and does not require pre-treatment with an esterase. Useful for non-cellular in vitro studies involving isolated, purified or recombinant caspase enzymes. Cell-permeable version also available - Z-VAD (OMe)-FMK ab120487.
SequenceVAD (Modifications: N-terminal benzyloxycarbonyl; C-terminal FMK)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 20 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Our Abpromise guarantee covers the use of ab120382 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Functional Studies||Use at an assay dependent concentration.|
This product has been referenced in:
- Vandenabeele P et al. Caspase inhibitors promote alternative cell death pathways. Sci STKE 2006:pe44 (2006). Read more (PubMed: 17062895) »
- Ekert PG et al. Caspase inhibitors. Cell Death Differ 6:1081-6 (1999). Read more (PubMed: 10578177) »
- Garcia-Calvo M et al. Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem 273:32608-13 (1998). Read more (PubMed: 9829999) »