Z-VRPR-FMK (Z-Val-Arg-Pro-DL-Arg-FMK, MALT1 inhibitor), MALT1 inhibitor (ab144390)

Overview

  • Product name

    Z-VRPR-FMK (Z-Val-Arg-Pro-DL-Arg-FMK, MALT1 inhibitor), MALT1 inhibitor
  • Description

    Selective, cell-permeable and irreversible MALT1 inhibitor
  • Biological description

    Selective, cell-permeable and irreversible MALT1 inhibitor. Inhibits NF-κB-dependent gene expression. Shows antiproliferative effects to B cells.
  • Purity

    > 94%
  • CAS Number

    1381885-28-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Mc Guire C  et al. Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis. J Neuroinflammation 11:124 (2014). Read more (PubMed: 25043939) »
  • Fontán L & Melnick A Molecular pathways: targeting MALT1 paracaspase activity in lymphoma. Clin Cancer Res 19:6662-8 (2013). Read more (PubMed: 24004675) »
  • Rebeaud F  et al. The proteolytic activity of the paracaspase MALT1 is key in T cell activation. Nat Immunol 9:272-81 (2008). Read more (PubMed: 18264101) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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