Overview

  • Product name

    Z-WEHD-FMK, caspase-1, caspase-5 and cathepsin B inhibitor
  • Description

    Cell permeable inhibitor of caspase-1, caspase-5 and cathepsin B.
  • Biological description

    Cell permeable inhibitor of caspase-1, caspase-5 and cathepsin B (IC50 = 6 µM). Inhibits apoptosis in multiple biological systems.
  • Purity

    > 99%
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Newman ZL  et al. CA-074Me protection against anthrax lethal toxin. Infect Immun 77:4327-36 (2009). Read more (PubMed: 19635822) »
  • Chae JJ  et al. The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Proc Natl Acad Sci U S A 103:9982-7 (2006). Read more (PubMed: 16785446) »
  • Naito T  et al. Anticancer mechanisms of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl) cytosine (ECyd, TAS-106). Nucleic Acids Res Suppl :241-2 (2002). Read more (PubMed: 12903195) »

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