Overview

  • Product name

    Zanamivir, Antiviral agent
  • Description

    Antiviral. Neuraminidase inhibitor
  • Biological description

    Antiviral. Neuraminidase inhibitor. Binds active site of neuraminidase protein, preventing influenza virus escape from host. Inhibitor of virus replication in vitro and in vivo.
  • Purity

    > 98%
  • CAS Number

    139110-80-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2R,3R,4S)-3-Acetamido-4-(diaminomethylideneamino)-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
  • Molecular weight

    332.31
  • Molecular formula

    C12H20N4O7
  • PubChem identifier

    60855
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)NC1C(C=C(OC1C(C(CO)O)O)C(=O)O)N=C(N)N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Menéndez-Arias L & Gago F Antiviral agents: structural basis of action and rational design. Subcell Biochem 68:599-630 (2013). Read more (PubMed: 23737066) »
  • Stittelaar KJ  et al. Evaluation of intravenous zanamivir against experimental influenza A (H5N1) virus infection in cynomolgus macaques. Antiviral Res 80:225-8 (2008). Read more (PubMed: 18647621) »
  • Deriabin PG  et al. [Effect of Zanamivir substance on infection induced by highly pathogenic avian influenza A/H5N1 in cell cultures]. Vopr Virusol 56:21-4 (0). Read more (PubMed: 21427950) »

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