Overview

  • Product name

  • Description

    Rabbit polyclonal to ZCH11
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Dog, Chimpanzee, Ferret, Gorilla, Chinese hamster
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 250-300 of Human ZCH11 (NP_056084.1)

  • Positive control

    • Human prostate carcinoma tissue, Mouse teratoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab128180 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Uridylyltransferase that acts as a suppressor of microRNA (miRNA) biogenesis by specifically mediating the terminal uridylation of some miRNAs. Catalyzes the 3' uridylation of precursor let-7 (pre-let-7), a miRNA precursor. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 contributes to the maintenance of embryonic stem (ES) cells and is required for ES cells to maintain pluripotency. Does not bind RNA by itself, recruited to pre-let-7 miRNAs via its interaction with LIN28A and LIN28B. Also catalyzes the 3' uridylation of miR-26A, a miRNA that represses IL6 transcript, leading to abrogate IL6 transcript repression and promote cytokine expression. May also suppress Toll-like receptor-induced NF-kappa-B activity via binding to T2BP. Does not play a role in replication-dependent histone mRNA degradation.
  • Sequence similarities

    Belongs to the DNA polymerase type-B-like family.
    Contains 3 CCHC-type zinc fingers.
    Contains 2 PAP-associated domains.
  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Nucleus. Cytoplasm. Translocates into the cytoplasm following treatment of the cell with LPS.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp779C1943 antibody
    • EC 2.7.7.52 antibody
    • FLJ42878 antibody
    • KIAA0191 antibody
    • PAP associated domain containing 3 antibody
    • PAPD3 antibody
    • Terminal uridylyltransferase 4 antibody
    • TUT4 antibody
    • TUT4_HUMAN antibody
    • TUTase 4 antibody
    • ZCCHC 11 antibody
    • Zcchc11 antibody
    • Zinc finger CCHC domain containing 11 antibody
    • Zinc finger CCHC domain containing protein 11 antibody
    • Zinc finger CCHC domain-containing protein 11 antibody
    see all

Images

  • ab128180, at 1/250 dilution, labelling ZCH11 in formalin-fixed, paraffin-embedded Human prostate carcinoma tissue by immunohistochemistry followed by DAB staining.
  • ab128180, at 1/250 dilution, labelling ZCH11 in formalin-fixed, paraffin-embedded Mouse teratoma tissue by immunohistochemistry followed by DAB staining.

References

ab128180 has not yet been referenced specifically in any publications.

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