Overview

  • Product name
    ZD7288, Sino-atrial node function modulator
  • Description
    Sino-atrial node function modulator
  • Alternative names
    • ICI D7288
  • Biological description
    Sino-atrial node function modulator; blocks the hyperpolarisation activated inward current If. Also inhibits Ih in central neurons and inhibits synaptic transmission.
  • Purity
    > 98%
  • CAS Number
    133059-99-1
  • Chemical structure
    Chemical Structure

Properties

Images

  • Membrane currents during slow voltage ramps from ?120 mV to ?40 mV in the presence of TTX (0.5 µM) and ZD7288 (50 µM), and during subsequent bath application of CCh (light grey line; 50 µM; B1) show that cholinergic receptor activation induces an inward current at voltages near resting membrane potential that reverses around ?76 mV, consistent the blockade of outward K+ currents. The application of CCh occluded additional inward current during subsequent bath application of XE-991 (dark grey line; 10 µM) sµggesting that CCh depolarizes PaS neurons in part by suppression of the M-current. Current subtractions show that CCh blocks an outward current that reverses at ?83.3±7.0 mV (black line; B2), and also occluded membrane currents normally induced by XE-991 (grey line).

References

This product has been referenced in:
  • Inaba Y  et al. The H current blocker ZD7288 decreases epileptiform hyperexcitability in the rat neocortex by depressing synaptic transmission. Neuropharmacology 51:681-91 (2006). Read more (PubMed: 16806308) »
  • Harris NC & Constanti A Mechanism of block by ZD 7288 of the hyperpolarization-activated inward rectifying current in guinea pig substantia nigra neurons in vitro. J Neurophysiol 74:2366-78 (1995). Read more (PubMed: 8747199) »
  • BoSmith RE  et al. Inhibitory actions of ZENECA ZD7288 on whole-cell hyperpolarization activated inward current (If) in guinea-pig dissociated sinoatrial node cells. Br J Pharmacol 110:343-9 (1993). Read more (PubMed: 7693281) »
See all 16 Publications for this product

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