Overview

  • Product name

    Zearalenone (ZEA), ERalpha and ERbeta ligand
  • Description

    Mixed potent, nonsteroidal ERα and ERβ ligand. Mycotoxin.
  • Biological description

    Mixed potent, nonsteroidal ERα and ERβ ligand (IC50 values are 56 and 41 nM for ERα and ERβ respectively). Shows agonist effects at lower doses. Partially selective for ERα activation. Induces apoptosis in male germ cells. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    17924-92-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Duca RC  et al. In vivo effects of zearalenone on the expression of proteins involved in the detoxification of rat xenobiotics. Environ Toxicol 27:98-108 (2012). Read more (PubMed: 20607812) »
  • Jee Y  et al. Involvement of the Fas and Fas ligand in testicular germ cell apoptosis by zearalenone in rat. J Vet Sci 11:115-9 (2010). Read more (PubMed: 20458151) »
  • Mueller SO  et al. Phytoestrogens and their human metabolites show distinct agonistic and antagonistic properties on estrogen receptor alpha (ERalpha) and ERbeta in human cells. Toxicol Sci 80:14-25 (2004). Read more (PubMed: 15084758) »
See 1 Publication for this product

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