Overview

  • Product name

    Zebularine, DNA methyltransferase (DNMT) inhibitor
  • Description

    DNA methyltransferase (DNMT) inhibitor
  • Biological description

    DNA methyltransferase( DNMT) inhibitor and cytidine deaminase inhibitor (Ki = 2 µM). Inhibits tumour growth in vitro and in vivo.
  • Purity

    > 99%
  • CAS Number

    3690-10-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Ruiz-Magaña MJ  et al. The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells. Int J Cancer 130:1195-207 (2012). Read more (PubMed: 21455989) »
  • Chen M  et al. DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer. Mol Cancer Ther 11:370-82 (2012). Read more (PubMed: 22203734) »
  • Kim HJ  et al. DNMT (DNA methyltransferase) inhibitors radiosensitize human cancer cells by suppressing DNA repair activity. Radiat Oncol 7:39 (2012). Read more (PubMed: 22429326) »
  • Zhou L  et al. Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. J Mol Biol 321:591-9 (2002). Read more (PubMed: 12206775) »

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