Overview

  • Product name

    Zerumbone, NF-kappaB inhibitor
  • Description

    Potent NF-κB inhibitor. Anticancer agent.
  • Biological description

    Potent NF-κB inhibitor. Anticancer agent. Induces cytochrome c dependent caspase activation and mitochondrial permeabilisation in cancer cells. Induces apoptosis and shows anti-inflammatory and antitumor effects in vivo. Orally active.
  • Purity

    > 96%
  • CAS Number

    471-05-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Sobhan PK  et al. Calpain and reactive oxygen species targets bax for mitochondrial permeabilisation and caspase activation in zerumbone induced apoptosis. PLoS One 8:e59350 (2013). Read more (PubMed: 23593137) »
  • Chen BY  et al. Dietary zerumbone prevents mouse cornea from UVB-induced photokeratitis through inhibition of NF-?B, iNOS, and TNF-a expression and reduction of MDA accumulation. Mol Vis 17:854-63 (2011). Read more (PubMed: 21527993) »
  • Xian M  et al. Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway. Cancer Sci 98:118-26 (2007). Read more (PubMed: 17129359) »
  • Takada Y  et al. Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion. Oncogene 24:6957-69 (2005). Read more (PubMed: 16007145) »

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