Key features and details
- Sheep polyclonal to ZIC3
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
Product nameAnti-ZIC3 antibody
See all ZIC3 primary antibodies
DescriptionSheep polyclonal to ZIC3
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse
Predicted to work with: Human
- Mouse embryonic tissue lysate.
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We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferConstituent: 100% PBS
Concentration information loading...
PurityImmunogen affinity purified
Purification notesThe IgG fraction of immunized serum was purified by antigen affinity chromatography.
Our Abpromise guarantee covers the use of ab215063 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000 - 1/2000. Detects a band of approximately 56 kDa (predicted molecular weight: 50 kDa).|
FunctionActs as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
Involvement in diseaseHeterotaxy, visceral, 1, X-linked
VACTERL association X-linked with or without hydrocephalus
Congenital heart defects, multiple types, 1, X-linked
Sequence similaritiesBelongs to the GLI C2H2-type zinc-finger protein family.
Contains 5 C2H2-type zinc fingers.
DomainThe C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.
Cellular localizationNucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6.
- Information by UniProt
- Heterotaxy 1 antibody
- HTX antibody
- HTX1 antibody
Anti-ZIC3 antibody (ab215063) at 1/1000 dilution + Mouse embryonic tissue lysate
Predicted band size: 50 kDa
Observed band size: 56 kDa why is the actual band size different from the predicted?
ab215063 has been referenced in 1 publication.
- Yamanishi A et al. Collection of homozygous mutant mouse embryonic stem cells arising from autodiploidization during haploid gene trap mutagenesis. Nucleic Acids Res 46:e63 (2018). PubMed: 29554276