Zidovudine (Retrovir), nucleoside reverse-transcriptase inhibitor (NRTI) (ab143266)

Overview

  • Product name

    Zidovudine (Retrovir), nucleoside reverse-transcriptase inhibitor (NRTI)
  • Description

    Nucleoside reverse-transcriptase inhibitor (NRTI)
  • Biological description

    Nucleoside reverse-transcriptase inhibitor (NRTI). Antiretroviral, Blood brain barrier permeable.
  • Purity

    > 99%
  • CAS Number

    30516-87-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[(2R,4S,5S)-4-Azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
  • Molecular weight

    267.24
  • Molecular formula

    C10H13N5O4
  • PubChem identifier

    35370
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Gajbhiye V  et al. Synthesis, characterization and targeting potential of zidovudine loaded sialic acid conjugated-mannosylated poly(propyleneimine) dendrimers. Eur J Pharm Sci 48:668-79 (2013). Read more (PubMed: 23298577) »
  • Sankar V  et al. Comparative studies of lamivudine-zidovudine nanoparticles for the selective uptake by macrophages. Curr Drug Deliv 9:506-14 (2012). Read more (PubMed: 22452408) »
  • Das MK & Yelhounganba Khuman L Ex vivo permeation kinetics of zidovudine from pseudolatex acrylic film across pig ear epidermis. Curr Drug Deliv 9:468-76 (2012). Read more (PubMed: 22758649) »

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