Key features and details
- Rabbit polyclonal to Zinc finger antiviral protein
- Suitable for: ICC/IF, WB, ICC
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Zinc finger antiviral protein antibody
See all Zinc finger antiviral protein primary antibodies
DescriptionRabbit polyclonal to Zinc finger antiviral protein
Specificityab105357 is predicted to not crossreact with other ZAP members. Four isoforms of Zinc finger antiviral protein are known to exist.
Tested applicationsSuitable for: ICC/IF, WB, ICCmore details
Species reactivityReacts with: Human
Synthetic peptide corresponding to Human Zinc finger antiviral protein (C terminal).
Database link: NP_078901
- WB: HeLa cell lysate ICC: HeLa cells
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Storage instructionsShipped at 4°C. Store at +4°C.
Storage bufferpH: 7.2
Preservative: 0.02% Sodium azide
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab105357 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|ICC/IF||Use a concentration of 20 µg/ml.|
|WB||Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 101 kDa.|
|ICC||Use a concentration of 20 µg/ml.|
FunctionInduces an innate immunity to viral infections by preventing the accumulation of viral RNAs in the cytoplasm. Seems to recruit the RNA processing exosome to degrade the target RNAs. Inhibits alphavirus and filovirus replication.
Sequence similaritiesContains 4 C3H1-type zinc fingers.
Contains 1 PARP catalytic domain.
Contains 1 WWE domain.
DomainThe second and fourth zinc fingers are involved in binding to specific viral RNAs.
Cellular localizationCytoplasm. Nucleus. Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner.
- Information by UniProt
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Anti-Zinc finger antiviral protein antibody (ab105357) at 1 µg/ml + HeLa cell lysate at 15 µg
Predicted band size: 101 kDa
Immunocytochemical analysis of Zinc finger antiviral protein in HeLa cells stained with ab105357 at 20 µg/ml.
Immunofluorescence of ZC3HAV1 in Hela cells using ab105357 at 20 ug/ml.
ab105357 has been referenced in 1 publication.
- Lee H et al. Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus. Proc Natl Acad Sci U S A 110:12379-84 (2013). PubMed: 23836649