Anti-Zinc finger antiviral protein antibody (ab73369)

This fast track antibody is not yet fully characterized. It is subject to these terms and conditions.


  • Product name

    Anti-Zinc finger antiviral protein antibody
    See all Zinc finger antiviral protein primary antibodies
  • Description

    Rabbit polyclonal to Zinc finger antiviral protein

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • Host species

  • Species reactivity

    Predicted to work with: Human, Chimpanzee, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide corresponding to Human Zinc finger antiviral protein aa 300-400 conjugated to keyhole limpet haemocyanin.
    (Peptide available as ab73368)


  • Form

  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    Preservative: 0.02% Sodium Azide
    Constituents: 1% BSA, PBS, pH 7.4
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

  • Isotype

  • Research areas


Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA). Fast track terms of use

Application Abreviews Notes
ELISA Use at an assay dependent concentration. : This antibody gave a positive result in ELISA against the immunizing peptide (ab73368).
ICC/IF Use a concentration of 1 µg/ml.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • Function

    Induces an innate immunity to viral infections by preventing the accumulation of viral RNAs in the cytoplasm. Seems to recruit the RNA processing exosome to degrade the target RNAs. Inhibits alphavirus and filovirus replication.
  • Sequence similarities

    Contains 4 C3H1-type zinc fingers.
    Contains 1 PARP catalytic domain.
    Contains 1 WWE domain.
  • Domain

    The second and fourth zinc fingers are involved in binding to specific viral RNAs.
  • Cellular localization

    Cytoplasm. Nucleus. Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner.
  • Information by UniProt
  • Database links

  • Alternative names

    • ADP ribosyltransferase diphtheria toxin like 13 antibody
    • ARTD13 antibody
    • FLB6421 antibody
    • PARP13 antibody
    • ZAP antibody
    • ZC3H2 antibody
    • ZC3HAV 1 antibody
    • Zc3hav1 antibody
    • ZC3HDC 2 antibody
    • ZC3HDC2 antibody
    • ZCCHV antibody
    • ZCCHV_HUMAN antibody
    • Zinc finger antiviral protein antibody
    • Zinc finger CCCH domain containing protein 2 antibody
    • Zinc finger CCCH domain-containing antiviral protein 1 antibody
    • Zinc finger CCCH domain-containing protein 2 antibody
    • Zinc finger CCCH type antiviral 1 antibody
    • Zinc finger CCCH type antiviral protein 1 antibody
    • Zinc finger CCCH-type antiviral protein 1 antibody
    see all


This Fast-Track antibody is not yet fully characterised. These images represent inconclusive preliminary data.

  • ICC/IF image of ab73369 stained HeLa cells. The cells were 4% PFA fixed (10 min), permabilised in 0.1% PBS-Tween (20 min) and incubated with the antibody (ab73369, 1µg/ml) for 1h at room temperature. 1%BSA / 10% normal goat serum / 0.3M glycine was used to block non-specific protein-protein interactions. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red). DAPI was used to stain the cell nuclei (blue). This antibody also gave a positive IF result in 100$% methanol fixed (5 mins) HePG2 and MCF7 cells. However, this Fast-Track antibody is not yet fully characterised. This image represents inconclusive preliminary data.
  • IHC image of Zinc finger antiviral protein staining in Human Normal Kidney FFPE section, performed on a BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab73369, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.


This product has been referenced in:

  • Liu CH  et al. Battle between influenza A virus and a newly identified antiviral activity of the PARP-containing ZAPL protein. Proc Natl Acad Sci U S A 112:14048-53 (2015). Read more (PubMed: 26504237) »
  • Gläsker S  et al. The alternate triad motif of the poly(ADP-ribose) polymerase-like domain of the human zinc finger antiviral protein is essential for its antiviral activity. J Gen Virol 95:816-22 (2014). WB ; Human . Read more (PubMed: 24457973) »
See all 3 Publications for this product

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