Product nameZinc pyrithione, Antifungal agent
DescriptionAntifungal agent. Potent KV7 channel activator.
Biological descriptionAntibiotic agent. Potent KV7 channel activator. Augments KCNQ1, -2, -4, and 5 channel currents. Fungal membrane transport inhibitor. Shows fungistatic and bacteriostatic effects in vivo.
Chemical name1-Oxidopyridine-2-thione zinc
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 75 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Brueggemann LI et al. KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a ß2-adrenergic agonist enhances relaxation of rat airways. Am J Physiol Lung Cell Mol Physiol 306:L476-86 (2014). Read more (PubMed: 24441871) »
- Zhou P et al. Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels. Proc Natl Acad Sci U S A 110:8726-31 (2013). Read more (PubMed: 23650395) »
- Chandler CJ & Segel IH Mechanism of the antimicrobial action of pyrithione: effects on membrane transport, ATP levels, and protein synthesis. Antimicrob Agents Chemother 14:60-8 (1978). Read more (PubMed: 28693) »