Zinc pyrithione, Antifungal agent (ab145748)

Overview

  • Product name

    Zinc pyrithione, Antifungal agent
  • Description

    Antifungal agent. Potent KV7 channel activator.
  • Biological description

    Antibiotic agent. Potent KV7 channel activator. Augments KCNQ1, -2, -4, and 5 channel currents. Fungal membrane transport inhibitor. Shows fungistatic and bacteriostatic effects in vivo.
  • CAS Number

    13463-41-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-Oxidopyridine-2-thione zinc
  • Molecular weight

    317.70
  • Molecular formula

    C10H8N2O2S2Zn
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 75 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Brueggemann LI  et al. KCNQ (Kv7) potassium channel activators as bronchodilators: combination with a ß2-adrenergic agonist enhances relaxation of rat airways. Am J Physiol Lung Cell Mol Physiol 306:L476-86 (2014). Read more (PubMed: 24441871) »
  • Zhou P  et al. Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels. Proc Natl Acad Sci U S A 110:8726-31 (2013). Read more (PubMed: 23650395) »
  • Chandler CJ & Segel IH Mechanism of the antimicrobial action of pyrithione: effects on membrane transport, ATP levels, and protein synthesis. Antimicrob Agents Chemother 14:60-8 (1978). Read more (PubMed: 28693) »

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