Overview

  • Product name

    Zinpyr-1, Fluorogenic Zn2+ reporter
  • Description

    Cell-permeable fluorogenic Zn2+ reporter
  • Biological description

    Cell-permeable fluorogenic Zn2+ reporter. 2,7-Dichlorofluorescein (ab146332) derivative. Induces positive fluorescence upon metal ion complexation. PET sensor.
  • Purity

    > 95%
  • CAS Number

    288574-78-7
  • Chemical structure

    Chemical Structure

Properties

  • Excitation

    515nm
  • Emission

    515nm
  • Chemical name

    4′,5′-Bis[bis(2-pyridylmethyl)aminomethyl]-2′,7′-dichlorofluorescein
  • Molecular weight

    823.72
  • Molecular formula

    C46H36Cl2N6O5
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    Oc8c(CN(Cc1ccccn1)Cc2ccccn2)c9Oc5c(CN(Cc3ccccn3)Cc4ccccn4)c(O)c(Cl)cc5C7(OC(=O)c6ccccc67)c9cc8Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Figueroa JA  et al. Selectivity and specificity of small molecule fluorescent dyes/probes used for the detection of Zn2+ and Ca2+ in cells. Metallomics 6:301-15 (2014). Read more (PubMed: 24356796) »
  • Goldsmith CR & Lippard SJ Analogues of Zinpyr-1 provide insight into the mechanism of zinc sensing. Inorg Chem 45:6474-8 (2006). Read more (PubMed: 16878961) »
  • Malavolta M  et al. Single and three-color flow cytometry assay for intracellular zinc ion availability in human lymphocytes with Zinpyr-1 and double immunofluorescence: relationship with metallothioneins. Cytometry A 69:1043-53 (2006). Read more (PubMed: 16998866) »
See all 2 Publications for this product

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