Anti-ZIP-13 antibody (ab106586)
Key features and details
- Rabbit polyclonal to ZIP-13
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-ZIP-13 antibody -
Description
Rabbit polyclonal to ZIP-13 -
Host species
Rabbit -
Specificity
At least two isoforms of ZIP-13 are known to exist; ab106586 will detect both isoforms. ab106586 is predicted to not crossreact with other ZIP family members. -
Tested applications
Suitable for: ICC/IF, WB, IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human ZIP-13 (N terminal).
Database link: NP_001121697 -
Positive control
- K562 cell lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at 4°C (stable for up to 12 months). -
Storage buffer
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab106586 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ICC/IF |
Use a concentration of 20 µg/ml.
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WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 39 kDa.
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IHC-P |
Use at an assay dependent concentration.
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Notes |
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ICC/IF
Use a concentration of 20 µg/ml. |
WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 39 kDa. |
IHC-P
Use at an assay dependent concentration. |
Target
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Function
Acts as a zinc-influx transporter. -
Involvement in disease
Defects in SLC39A13 are the cause of Ehlers-Danlos syndrome-like spondylocheirodysplasia (SCD-EDS) [MIM:612350]. SCD-EDS is a 'spondylocheiro dysplastic form of Ehlers-Danlos syndrome'. The syndrome consists of a generalized skeletal dysplasia involving mainly the spine (spondylo) and striking clinical abnormalities of the hands (cheiro) in addition to the EDS-like features. Clinical features included postnatal growth retardation, moderate short stature, protuberant eyes with bluish sclerae, hands with finely wrinkled palms, atrophy of the thenar muscles, and tapering fingers. Patients have thin, hyperelastic skin and hypermobile small joints consistent with an Ehlers-Danlos-like phenotype. Radiologic features included mild to moderate platyspondyly, mild to moderate osteopenia of the spine, small ileum, flat proximal femoral epiphyses, short, wide femoral necks, and broad metaphyses (elbows, knees, wrists, and interphalangeal joints). -
Sequence similarities
Belongs to the ZIP transporter (TC 2.A.5) family. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 91252 Human
- Omim: 608735 Human
- SwissProt: Q96H72 Human
- Unigene: 523664 Human
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Form
There are 2 isoforms produced by alternative splicing. -
Alternative names
- FLJ25785 antibody
- LIV-1 subfamily of ZIP zinc transporter 9 antibody
- LZT-Hs9 antibody
see all
Images
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab106586 has been referenced in 2 publications.
- Chen Z et al. Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1/2 signalling pathway. Cardiovasc Res 117:820-835 (2021). PubMed: 32259211
- Cheng X et al. Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human ovarian cancer cells via activating Src/FAK signaling pathway. J Exp Clin Cancer Res 40:199 (2021). PubMed: 34154618