Overview

  • Product name

  • Description

    Rabbit polyclonal to ZIP-5
  • Host species

    Rabbit
  • Specificity

    ab105194 is predicted not to cross-react with other ZIP family members.
  • Tested applications

    Suitable for: ICC/IF, WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to Human ZIP-5 (internal sequence).
    Database link: NP_001128667

  • Positive control

    • Human spleen tissue lysate
  • General notes

    Previously labelled as SLC39A5.

Properties

Applications

Our Abpromise guarantee covers the use of ab105194 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 56 kDa.
IHC-P Use at an assay dependent concentration.

Target

  • Function

    May play a role in polarized cells by carrying out serosal-to-mucosal zinc transport. Plays a role in eye development. Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Seems to play a central role in controlling organismal zinc status.
  • Tissue specificity

    Expressed in liver, kidney, pancreas, small intestine, colon, spleen, fetal liver and fetal kidney.
  • Involvement in disease

    Myopia 24, autosomal dominant
  • Sequence similarities

    Belongs to the ZIP transporter (TC 2.A.5) family.
  • Post-translational
    modifications

    Glycosylated.
  • Cellular localization

    Basolateral cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • LZT Hs7 antibody
    • MGC34778 antibody
    • OTTHUMP00000211153 antibody
    • OTTHUMP00000211154 antibody
    • S39A5_HUMAN antibody
    • SLC39A5 antibody
    • solute carrier family 39 (metal ion transporter), member 5 antibody
    • Solute carrier family 39 member 5 antibody
    • Zinc transporter ZIP5 [Precursor] antibody
    • Zinc transporter ZIP5 antibody
    • ZIP 5 antibody
    • ZIP-5 antibody
    • ZIP5 antibody
    • Zrt and Irt like protein 5 antibody
    • Zrt- and Irt-like protein 5 antibody
    see all

Images

  • Anti-ZIP-5 antibody (ab105194) at 1 µg/ml + Human spleen tissue lysate at 15 µg

    Predicted band size: 56 kDa

  • Immunofluorescence of ZIP-5 in Human spleen tissue with ab105194 at 20 ug/mL.

  • Immunohistochemistry of ZIP-5 in Human spleen tissue with ab105194 at 2.5 μg/mL.

References

ab105194 has not yet been referenced specifically in any publications.

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