Description

  • Product name

    ZIP Kinase peptide substrate
    See all ZIP Kinase proteins and peptides
  • Accession

  • Animal free

    No
  • Nature

    Synthetic
    • Species

      Human
    • Sequence

      KKLNRTLSFAEPG
    • Predicted molecular weight

      1461 kDa
  • Description

    Human ZIP Kinase peptide

Specifications

Our Abpromise guarantee covers the use of ab204885 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    HPLC

    Functional Studies

  • Form

    Lyophilised
  • Additional notes

    ab204885 (ZIP Kinase peptide substrate) can be utilized as a substrate for the following active protein kinases:

     

    ab102551 (Active human MELK protein fragment)
    ab101715 (Active human PHKG1 full length protein)
    ab89857 (Active human PHKG2 full length protein)

     

     

     

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Dilute peptide in 25mM Tris-HCl buffer (pH 7.5) to a final concentration of 1mg/ml

General Info

  • Alternative names

    • DAP kinase 3
    • DAP like kinase
    • DAP-like kinase
    • Dapk 3
    • DAPK3
    • DAPK3_HUMAN
    • Death associated kinase 3
    • Death associated protein kinase 3
    • Death-associated protein kinase 3
    • Dlk
    • EC 2.7.11.1
    • FLJ36473
    • MYPT1 kinase
    • ZIP
    • ZIP kinase
    • ZIP kinase isoform
    • ZIP-kinase
    • ZIPK
    • zipper-interacting protein kinase
    see all
  • Function

    Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Regulates myosin light chain phosphatase through phosphorylation of MYPT1 thereby regulating the assembly of the actin cytoskeleton, cell migration, invasiveness of tumor cells, smooth muscle contraction and neurite outgrowth. Involved in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection.
  • Sequence similarities

    Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    Ubiquitinated. Ubiquitination mediated by the UBE2D3 E3 ligase does not lead to proteasomal degradation, but influences promyelocytic leukemia protein nuclear bodies (PML-NBs) formation in the nucleus.
    Autophosphorylated. Phosphorylated by ROCK1.
  • Cellular localization

    Nucleus. Cytoplasm. Nucleus > PML body. Relocates to the cytoplasm on binding PAWR where the complex appears to interact with actin filaments (By similarity). Localizes to promyelocytic leukemia protein nuclear bodies (PML-NBs). Associates to centromeres from prophase to anaphase.
  • Information by UniProt

References

ab204885 has not yet been referenced specifically in any publications.

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