Overview

  • Product name

    ZIP, protein kinase Mzeta (PKMzeta) inhibitor
  • Description

    Novel, cell-permeable protein kinase Mζ (PKMζ) inhibitor
  • Alternative names

    • z-Pseudosubstrate inhibitory peptide
  • Biological description

    Novel, cell-permeable PKMζ inhibitor, a constitutively active, atypical PKC isozyme. Efficacious in in vitro and in vivo models of synaptic plasticity (IC50 = 1 - 2.5 μM).
  • Purity

    > 94%
  • CAS Number

    863987-12-6
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    1928.40
  • Molecular formula

    C90H154N30O17
  • Sequence

    SIYRRGARRWRKL (Modifications: N-terminal myristyl)
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Wu-Zhang AX  et al. Cellular pharmacology of protein kinase M? (PKM?) contrasts with its in vitro profile: implications for PKM? as a mediator of memory. J Biol Chem 287:12879-85 (2012). Read more (PubMed: 22378786) »
  • Cai D  et al. Protein kinase M maintains long-term sensitization and long-term facilitation in aplysia. J Neurosci 31:6421-31 (2011). Read more (PubMed: 21525283) »
  • Serrano P  et al. Persistent phosphorylation by protein kinase Mzeta maintains late-phase long-term potentiation. J Neurosci 25:1979-84 (2005). Read more (PubMed: 15728837) »

Customer reviews and Q&As

Answer



Generally, we check all vials after freeze drying to satisfy ourselves that there is product in the vial, but it isn’t always possible to see a nice fluffy plug of material in the bottom of the vial; sometimes the result is a thin film coating the inside of the vial. This difference can occur for the same product when freeze dried at different times and very occasionally you can get two different appearances in a single session. So, it might well be that, although we have supplied the material as a single batch it was produced in two different freeze drying sessions and therefore, for example, 2 vials contain an easy to see plug of material while the other 3 have the material coating the vial.

Just by way of further reassurance we went to our existing stock and can confirm that at first glance the vial did look empty, but when I removed the label and held it up to the light I could clearly see a thin coating extending about ¼” up from the bottom of the vial which had a very subtle bluish hue to it. Although we wouldn’t routinely suggest removing labels from our products due to the obvious opportunity for confusion to then occur, if the customer is careful they might be able to unpeel the label (such that it could be re-applied) and then check the vials by holding up to the light.

I appreciate that there is a lot of information above, but put simply the product is prepared in such a way that it can cause it to coat the vial, therefore making it difficult to see. We visually check all of the vials that are produced in this way to ensure that we are confident that the product is still in the vial.

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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