Key features and details
- Potent, selective A2A antagonist
- CAS Number: 139180-30-6
- Purity: > 99%
- Soluble in DMSO to 100 mM and in ethanol to 5 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Product nameZM 241385, A2A antagonist
DescriptionPotent, selective A2A antagonist
Potent A2 adenosine receptor antagonist, with approx 50-fold selectivity for A2A receptors. (Ki values are <1 nM, 50 nM, 255 nM and >10 μM at human cloned A2A, A2B, A1 and A3 receptors, respectively). Orally active in vivo.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 5 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120218 has been referenced in 1 publication.
- Basu M et al. Increased host ATP efflux and its conversion to extracellular adenosine is crucial for establishing Leishmania infection. J Cell Sci 133:N/A (2020). PubMed: 32079656