Product nameZM 336372, c-Raf inhibitor
DescriptionPotent, selective c-Raf inhibitor
Biological descriptionPotent, cell-permeable and selective c-Raf inhibitor (IC50 = 70 nM). Displays 10-fold selectivity over b-Raf. Inhibits carcinoid cell growth. Also inhibits growth and apoptosis in pancreatic cancer cells.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Research Area
- Alzheimer's Disease
- Signal transduction
- Raf kinase
This product has been referenced in:
- Deming D et al. ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines. J Surg Res 161:28-32 (2010). Read more (PubMed: 20031160) »
- Kunnimalaiyaan M et al. Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways. Surgery 142:959-64; discussion 959-64 (2007). Read more (PubMed: 18063082) »
- Hall-Jackson CA et al. Paradoxical activation of Raf by a novel Raf inhibitor. Chem Biol 6:559-68 (1999). Read more (PubMed: 10421767) »