Overview

  • Product name

    ZM 336372, c-Raf inhibitor
  • Description

    Potent, selective c-Raf inhibitor
  • Biological description

    Potent, cell-permeable and selective c-Raf inhibitor (IC50 = 70 nM). Displays 10-fold selectivity over b-Raf. Inhibits carcinoid cell growth. Also inhibits growth and apoptosis in pancreatic cancer cells.
  • Purity

    > 98%
  • CAS Number

    208260-29-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Deming D  et al. ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines. J Surg Res 161:28-32 (2010). Read more (PubMed: 20031160) »
  • Kunnimalaiyaan M  et al. Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways. Surgery 142:959-64; discussion 959-64 (2007). Read more (PubMed: 18063082) »
  • Hall-Jackson CA  et al. Paradoxical activation of Raf by a novel Raf inhibitor. Chem Biol 6:559-68 (1999). Read more (PubMed: 10421767) »

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