Overview

  • Product name
    ZM 449829, JAK3 inhibitor
  • Description
    Potent, selective, ATP-competitive JAK3 inhibitor. Potent transglutaminase inhibitor.
  • Biological description
    Potent, selective, ATP-competitive JAK3 inhibitor (pIC50 values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively). Potent transglutaminase inhibitor (IC50 = 10 nM). Inhibits STAT5 phosphorylation and T cell proliferation.
  • Purity
    > 98%
  • CAS Number
    4452-06-6
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    1-(2-Naphthalenyl)-2-propen-1-one
  • Molecular weight
    182.22
  • Molecular formula
    C13H10O
  • PubChem identifier
    3799
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C=CC(=O)C1=CC2=CC=CC=C2C=C1
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Lai TS  et al. Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries. Chem Biol 15:969-78 (2008). Read more (PubMed: 18804034) »
  • Gross ER  et al. The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta. Am J Physiol Heart Circ Physiol 291:H827-34 (2006). Read more (PubMed: 16517948) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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