ZM306416 hydrochloride, VEGFR1/2 tyrosine kinase activity inhibitor (ab144576)

Overview

  • Product name

    ZM306416 hydrochloride, VEGFR1/2 tyrosine kinase activity inhibitor
  • Description

    Potent and selective VEGFR1/2 tyrosine kinase activity inhibitor
  • Biological description

    Potent and selective VEGFR1/2 inhibitor (IC50 values are 100 nM and 2 μM for KDR and Flt respectively). Shows antiproliferative effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    196603-47-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Kawai T  et al. Inhibitor of vascular endothelial growth factor receptor tyrosine kinase attenuates cellular proliferation and differentiation to mature neurons in the hippocampal dentate gyrus after transient forebrain ischemia in the adult rat. Neuroscience 141:1209-16 (2006). Read more (PubMed: 16753262) »
  • Germani A  et al. Vascular endothelial growth factor modulates skeletal myoblast function. Am J Pathol 163:1417-28 (2003). Read more (PubMed: 14507649) »
  • Hennequin LF  et al. Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. J Med Chem 42:5369-89 (1999). Read more (PubMed: 10639280) »

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