Overview

  • Product name

  • Description

    Goat polyclonal to ZNF217
  • Host species

    Goat
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    C-KNAADDSADKVNKN

    (with a Cysteine residue linker), corresponding to amino acids 604-617 of Human ZNF217 (NP_006517.1).

  • Positive control

    • Human prostate tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab136678 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.03 µg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 115 kDa).
IHC-P Use a concentration of 3 - 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Binds to the promoters of target genes and functions as repressor. Promotes cell proliferation and antagonizes cell death. Promotes phosphorylation of AKT1 at 'Ser-473'.
  • Sequence similarities

    Belongs to the krueppel C2H2-type zinc-finger protein family.
    Contains 7 C2H2-type zinc fingers.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • ZABC 1 antibody
    • ZABC1 antibody
    • Zinc finger protein 217 antibody
    • ZN 217 antibody
    • ZN217 antibody
    • ZN217_HUMAN antibody
    • ZNF 217 antibody
    • ZNF217 antibody
    see all

Images

  • Immunohistochemical analysis of Paraffin-embedded Human prostate tissue labelling ZNF217 with ab136678 at 3.8 µg/ml.

References

This product has been referenced in:

  • Si W  et al. The coordination between ZNF217 and LSD1 contributes to hepatocellular carcinoma progress and is negatively regulated by miR-101. Exp Cell Res 379:1-10 (2019). Read more (PubMed: 30898548) »
  • Shi SJ  et al. LncRNA-ATB promotes trastuzumab resistance and invasion-metastasis cascade in breast cancer. Oncotarget 6:11652-63 (2015). WB . Read more (PubMed: 25871474) »
See all 4 Publications for this product

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