May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.
Ubiquitous. Mainly expressed in fetal tissues.
Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 18 C2H2-type zinc fingers. Contains 1 KRAB domain.
Immunofluorescence analysis of HeLa cells labeling ZNF224; produced using the purified version of this antibody. For IHC and IF applications, antibody purification with Protein A will be needed prior to use.