Anti-ZNF750 antibody (ab121730)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF750 antibody (ab121730)

    Key features and details

    • Rabbit polyclonal to ZNF750
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    Overview

    • Product name

      Anti-ZNF750 antibody
      See all ZNF750 primary antibodies

    • Description

      Rabbit polyclonal to ZNF750

    • Host species

      Rabbit

    • Tested applications

      Suitable for: IHC-Pmore details

    • Species reactivity

      Reacts with: Human

    • Immunogen

      antigen sequence, corresponding to amino acids 73-187 of Human ZNF750.

    • Positive control

      • Human stomach tissue.

    • General notes

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    Applications

    Our Abpromise guarantee covers the use of ab121730 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    Perform Heat Induced Epitope Retrieval (HIER) at pH 6 using a pressure boiler as heat source.

    Target

    • Tissue specificity

      Expressed in the skin, prostate, lung, placenta and thymus, and at low level in T-cells. Not expressed in peripheral blood leukocytes, pancreas and brain. Clearly expressed in primary keratinocytes but not in fibroblasts.

    • Involvement in disease

      Defects in ZNF750 are the cause of Seborrhea-like dermatitis with psoriasiform (SLDP) [MIM:610227]. SLDP is characterized by a chronic fine diffuse scaly erythematous rash on the face, particularly on the chin, nasolabial folds and eyebrows, around earlobes and over the scalp. The rash exacerbate in the winter, with emotional stress and after strenuous physical activity. Hyperkeratosis of skin over the elbows, knees, palms, soles and metacarpophalangeal joints is evident. There is no arthralgia, arthritis or neurological disorders.
    • Information by UniProt

    • Database links

      • Alternative names

        • Protein ZNF750 antibody
        • ZFP750 antibody
        • Zinc finger protein 750 antibody
        • ZN750_HUMAN antibody
        • ZNF750 antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF750 antibody (ab121730)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZNF750 antibody (ab121730)
        ab121730 at 1/125 dilution staining ZNF750in Paraffin-embedded Human Stomach tissue by Immunohistochemistry. Note: strong cytoplasmic positivity in parietal cells.

      References (0)

      Publishing research using ab121730? Please let us know so that we can cite the reference in this datasheet.

      ab121730 has not yet been referenced specifically in any publications.

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