Overview

  • Product name

  • Description

    Rabbit polyclonal to ZnT-7
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Cow
  • Immunogen

    Recombinant fragment corresponding to Human ZnT-7 aa 161-233.
    Sequence:

    HGGHGHSHGSGHGHSHSLFNGALDQAHGHVDHCHSHEVKHGAAHSHDHAH GHGHFHSHDGPSLKETTGPSRQI


    Database link: Q8NEW0

  • Positive control

    • IHC-P: Human small intestine tissue. ICC/IF: A431 cells.
  • General notes

    Previously labelled as SLC30A7.

Properties

Applications

Our Abpromise guarantee covers the use of ab224405 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml.

Fixation/Permeabilization: PFA/Triton X-100.

Target

  • Function

    Seems to facilitate zinc transport from the cytoplasm into the Golgi apparatus. Partly regulates cellular zinc homeostasis. Required with ZNT5 for the activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT5 and ZNT6 for the activation of TNAP.
  • Sequence similarities

    Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
  • Cellular localization

    Golgi apparatus > trans-Golgi network membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 1810059J10Rik antibody
    • 2610034N15Rik antibody
    • 4833428C12Rik antibody
    • AI467242 antibody
    • DKFZp686M0368 antibody
    • SLC30A7 antibody
    • Solute carrier family 30 (zinc transporter), member 7 antibody
    • Solute carrier family 30 member 7 antibody
    • Zinc transporter 7 antibody
    • ZnT-7 antibody
    • Znt-like transporter 2 antibody
    • ZNT7 antibody
    • ZNT7_HUMAN antibody
    • ZNTL2 antibody
    see all

Images

  • Paraffin-embedded human small intestine tissue stained for ZnT-7 using ab224405 at 1/50 dilution in immunohistochemical analysis.

  • PFA-fixed, Triton X-100 permeabilized A431 (human epidermoid carcinoma cell line) cells stained for ZnT-7 (green) using ab224405 at 4 µg/ml in ICC/IF.

References

ab224405 has not yet been referenced specifically in any publications.

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