Overview

  • Product name

  • Description

    Rabbit polyclonal to ZnT-8
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human ZnT-8 (internal sequence).

  • Positive control

    • HeLa membrane extract lysate (ab29547) can be used as a positive control in WB. K562 cell lysate.
  • General notes

    Previously labelled as Zinc transporter 8. 

Properties

Applications

Our Abpromise guarantee covers the use of ab136990 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 40 kDa.

Target

  • Function

    Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.
  • Tissue specificity

    In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive.
  • Sequence similarities

    Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.
  • Domain

    Contains a histidine-rich region, HXXXXXHNH-motif, which is a ligand for zinc.
  • Cellular localization

    Cell membrane. Cytoplasmic vesicle, secretory vesicle membrane. Associated with insulin and glucagon secretory granules.
  • Information by UniProt
  • Database links

  • Form

    There are 2 isoforms produced by alternative splicing. This antibody only recognises the larger form.
  • Alternative names

    • SLC30A8 antibody
    • solute carrier family 30 (zinc transporter), member 8 antibody
    • Solute carrier family 30 member 8 antibody
    • Zinc transporter 8 antibody
    • zinc transporter ZnT-8 antibody
    • ZnT-8 antibody
    • ZNT8 antibody
    • ZNT8_HUMAN antibody
    see all

Images

  • Anti-ZnT-8 antibody (ab136990) at 1/500 dilution + K562 cell lysate at 30 µg

    Predicted band size: 40 kDa

References

ab136990 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab136990.
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