Zoledronate disodium salt, bisphosphonate bone resorption inhibitor (ab143738)

Overview

  • Product name

    Zoledronate disodium salt, bisphosphonate bone resorption inhibitor
  • Description

    Bisphosphonate bone resorption inhibitor
  • Biological description

    Bisphosphonate bone resorption inhibitor. Zoledronic acid (ab141980) derivative. Inhibits FFP synthase. Inhibits osteoclast activity. Potent angiogenesis inhibitor. Shows antitumor effects in vivo.
  • Purity

    > 98%
  • CAS Number

    165800-07-7
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    388.11
  • Molecular formula

    C5H8N2Na2O7P2.4H2O
  • PubChem identifier

    23649597
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CN(C=N1)CC(O)(P(=O)(O)[O-])P(=O)(O)[O-].O.O.O.O.[Na+].[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Zwolak P & Dudek AZ Antineoplastic activity of zoledronic acid and denosumab. Anticancer Res 33:2981-8 (2013). Read more (PubMed: 23898050) »
  • Yuasa T  et al. Zoledronic acid - a multiplicity of anti-cancer action. Curr Med Chem 14:2126-35 (2007). Read more (PubMed: 17691952) »
  • Biernacka J  et al. Prediction of bioavailability of selected bisphosphonates using in silico methods towards categorization into a biopharmaceutical classification system. Acta Pol Pharm 70:877-82 (0). Read more (PubMed: 24147367) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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