Overview

  • Product name

    Zoledronic acid, FPP synthase inhibitor
  • Description

    Highly potent bisphosphonate. FPP synthase inhibitor.
  • Biological description

    Highly potent bisphosphonate. FPP synthase inhibitor. Inhibits osteoclastogenesis (IC50 = 15 nM). Inhibits ASM and FDPS. Activates PKC. Inhibits osteoclastic bone resorption, shows antihypocalcemic and antiangiogenic effects in vivo.
  • Purity

    > 98%
  • CAS Number

    118072-93-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1-Hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid
  • Molecular weight

    272.09
  • Molecular formula

    C5H10N2O7P2
  • PubChem identifier

    68740
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Ge XY  et al. Reactive Oxygen Species and Autophagy Associated Apoptosis and Limitation of Clonogenic Survival Induced by Zoledronic Acid in Salivary Adenoid Cystic Carcinoma Cell Line SACC-83. PLoS One 9:e101207 (2014). Read more (PubMed: 24963720) »
  • Rizzo A  et al. Zoledronic acid affects the cytotoxic effects of Chlamydia pneumoniae and the modulation of cytokine production in human osteosarcoma cells. Int Immunopharmacol 22:66-72 (2014). Read more (PubMed: 24975838) »
  • Nourinia R  et al. Safety of Intravitreal Zoledronic Acid, an Anti-angiogenic Bisphosphonate, in a Rat Model. J Ophthalmic Vis Res 9:44-9 (2014). Read more (PubMed: 24982731) »

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