Overview

  • Product name

    ZSTK474, ATP-competitve PI3K inhibitor
  • Description

    Potent, ATP-competitve PI3K inhibitor
  • CAS Number

    475110-96-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-[4-[2-(Difluoromethyl)benzimidazol-1-yl]-6-morpholin-4-yl-1,3,5-triazin-2-yl]morpholine
  • Molecular weight

    417.41
  • Molecular formula

    C19H21F2N7O2
  • PubChem identifier

    11647372
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1COCCN1C2=NC(=NC(=N2)N3C4=CC=CC=C4N=C3C(F)F)N5CCOCC5
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Bertazza L  et al. Synergistic antitumour activity of RAF265 and ZSTK474 on human TT medullary thyroid cancer cells. J Cell Mol Med : (2015). Read more (PubMed: 26081844) »
  • Kong D  et al. Effect of ZSTK474, a novel phosphatidylinositol 3-kinase inhibitor, on DNA-dependent protein kinase. Biol Pharm Bull 32:297-300 (2009). Read more (PubMed: 19182393) »
  • Kong D & Yamori T ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms. Cancer Sci 98:1638-42 (2007). Read more (PubMed: 17711503) »

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