Key features and details
- Potent, ATP-competitve PI3K inhibitor
- CAS Number: 475110-96-4
- Soluble in DMSO to 50 mM
- Form / State: Solid
- Source: Synthetic
Product nameZSTK474, ATP-competitve PI3K inhibitor
DescriptionPotent, ATP-competitve PI3K inhibitor
Potent, ATP-competitive PI3K inhibitor (IC50 values are 5, 16, 44 and 49 nM for PI3Kδ, PI3Kα, PI3Kβ and PI3Kγ respectively). Induces G1-phase arrest but not apoptosis. Shows potent antiproliferative effects. Shows antitumor effects in vivo. Orally active.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Epigenetics and Nuclear Signaling
- DNA / RNA
- DNA Damage & Repair
- DNA Damage Response
- DNA Damage Recognition
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab146194 has not yet been referenced specifically in any publications.